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Construction and expression of hepatitis B virus vector encoding TC-tagged core protein
Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 396-402 doi: 10.1007/s11684-009-0056-z
关键词: hepatitis B virus vector tetracysteine tag core protein
脂肪变性诱发肝癌发生机制——HCV核心基因转基因小鼠的经验教训 Review
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
《工程(英文)》 2021年 第7卷 第12期 页码 1797-1805 doi: 10.1016/j.eng.2021.08.019
丙型肝炎病毒(HCV)感染是全球慢性肝炎、肝硬化和肝细胞癌(HCC)的主要病因。在HCV的结构蛋白中,HCV核心蛋白具有调控基因转录、脂质代谢、细胞增殖、细胞凋亡和自噬的能力,所有这些都与HCC的发展密切相关。携带HCV核心基因的转基因小鼠表现出与慢性丙型肝炎患者的临床特征相似的年龄依赖性胰岛素抵抗、肝脂肪变性和HCC。一些饮食习惯的调整,包括限制热量和富含饱和脂肪酸(SFA)、反式脂肪酸(TFA)或胆固醇的饮食,被证明会影响HCV核心基因转基因小鼠的肝脏脂肪生成和肿瘤形成。这些饮食的改变除了调节肝纤维化过程和微环境外,还调节了肝细胞的应激和增殖,从而证实了饮
食习惯与脂肪变性相关的肝癌发生之间的密切联系。本文综述了HCV基因组转基因小鼠模型的研究结果,重点介绍了HCV核心基因转基因小鼠的研究结果,并讨论了HCV核心蛋白诱导脂肪变性和肝癌发生的机制,以及饮食习惯对脂肪变性所致肝癌的影响。
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第2期 页码 102-112 doi: 10.15302/J-FASE-2016100
关键词: plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0729-8
关键词: honeycomb core straight blade ultrasonic cutting tool pose postprocessor
Cunwen WANG, Xiaoling DUAN, Weiguo WANG, Zihao LI, Yuanhang QIN
《能源前沿(英文)》 2012年 第6卷 第4期 页码 413-419 doi: 10.1007/s11708-012-0212-z
关键词: lignocellulose dilute acid hydrolysis shrinking core model
Recent advances in gold-metal oxide core-shell nanoparticles: Synthesis, characterization, and their
Michelle Lukosi,Huiyuan Zhu,Sheng Dai
《化学科学与工程前沿(英文)》 2016年 第10卷 第1期 页码 39-56 doi: 10.1007/s11705-015-1551-1
关键词: core-shell characterization core-shell structure Different stability
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 70-76 doi: 10.1007/s11684-011-0119-9
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
关键词: protein kinase C ? signal transduction neurogenic disease
Property-performance relationship of core-shell structured black TiO photocatalyst for environmental
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1711-3
● Properties and performance relationship of CSBT photocatalyst were investigated.
关键词: Black TiO2 Core-shell structure Property-performance relationship Agro-industrial effluent Environmental remediation
Wheat gluten protein and its impacts on wheat processing quality
Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 279-287 doi: 10.15302/J-FASE-2019267
Before the advent of the wheat genomic era, a wide range of studies were conducted to understand the chemistry and functions of the wheat storage proteins, which are the major determinants of wheat flour the suitability of wheat flour for various end products, such as bread, noodles and cakes. Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing quality mainly depends on the gluten fractions. Gluten provides the unique extensibility and elasticity of dough that are essential for various wheat end products. Disulfide bonds are formed between cysteine residues, which is the chemical bases for the physical properties of dough. Based on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein. The percentage of UPP is positively related to the formation of disulfide bonds in the dough matrix. In the wheat genomic era, new glutenins with long repetitive central domains that contain a high number of consensus hexapeptide and nonapeptide motifs as well as high content of cysteine and glutamine residues should be targeted.
关键词: wheat gluten consensus motifs disulfide bonds SDS-unextractable polymeric protein glutenins gliadins processing quality storage protein
Experiment and calculation on seismic behavior of RC composite core walls with concealed steel truss
Wanlin CAO , Weihua CHANG , Changjun ZHAO , Jianwei ZHANG ,
《结构与土木工程前沿(英文)》 2009年 第3卷 第3期 页码 255-261 doi: 10.1007/s11709-009-0043-0
关键词: reinforced concrete steel truss core walls seismic performance
Yidan WANG, Renke KANG, Yan QIN, Qian MENG, Zhigang DONG
《机械工程前沿(英文)》 2021年 第16卷 第2期 页码 285-297 doi: 10.1007/s11465-021-0631-9
关键词: Nomex honeycomb core disc cutter inclined ultrasonic cutting machining quality
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 1131-1139 doi: 10.1007/s11705-023-2321-0
关键词: biomass riboflavin sodium phosphate silk protein multifunctional modification flame retardant
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
Mei WEN,Da-fei HUANG,Chang-qing XUN,Dong CHEN
《信息与电子工程前沿(英文)》 2015年 第16卷 第11期 页码 899-916 doi: 10.1631/FITEE.1500032
关键词: OpenCL Performance portability Multi-core/many-core CPU Analysis-based transformation
标题 作者 时间 类型 操作
Construction and expression of hepatitis B virus vector encoding TC-tagged core protein
Yuanyuan LIN MD, Xiaoming CHENG MS, Yuhu SONG MD, Peiyuan LI MD, Ying CHANG MM, Jinjian YAO MD, Jusheng LIN MD, PhD, Li ZHOU PhD, Leiming XU PhD,
期刊论文
脂肪变性诱发肝癌发生机制——HCV核心基因转基因小鼠的经验教训
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
期刊论文
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
期刊论文
Postprocessor development for ultrasonic cutting of honeycomb core curved surface with a straight blade
期刊论文
Establishment and verification of a shrinking core model for dilute acid hydrolysis of lignocellulose
Cunwen WANG, Xiaoling DUAN, Weiguo WANG, Zihao LI, Yuanhang QIN
期刊论文
Recent advances in gold-metal oxide core-shell nanoparticles: Synthesis, characterization, and their
Michelle Lukosi,Huiyuan Zhu,Sheng Dai
期刊论文
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
期刊论文
Property-performance relationship of core-shell structured black TiO photocatalyst for environmental
期刊论文
Wheat gluten protein and its impacts on wheat processing quality
Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM
期刊论文
Experiment and calculation on seismic behavior of RC composite core walls with concealed steel truss
Wanlin CAO , Weihua CHANG , Changjun ZHAO , Jianwei ZHANG ,
期刊论文
Effects of inclination angles of disc cutter on machining quality of Nomex honeycomb core in ultrasonic
Yidan WANG, Renke KANG, Yan QIN, Qian MENG, Zhigang DONG
期刊论文
Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin
期刊论文
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
期刊论文